Monday, June 11th 2018
Tuesday, June 12th 2018
CSF Day 18:00 AM | Breakfast and Registration |
8:30 AM | Introduction & Program Preview |
Morning Session Moderator: Tracey Mascaro | |
8:45 AM | Keynote: Prof. Antonios Zavaliangos, Ph.D., Drexel University, College of Engineering Gaining Insight Into Sticking Through Modeling |
9:45 AM | Jerry Klinzing, Merck Modeling the air pressure increase in tablets during compaction a step toward understanding tablet capping |
10:15 AM | Break |
10:30 AM | Sean Garner, AbbVie Predictive modeling for tooling optimization and tableting success using advanced modeling techniques |
11:00 AM | Pingjun Tang and Joe Bullard, Vertex A novel approach to powder elastic strain calculation in uniaxial compression test |
11:30 AM | Stephen W. Hoag and Raghunadha Reddy Seelam, University of Maryland, Baltimore Evaluation of the effects of tablet compression force and tableting speed on polyethylene oxide polymers in abuse deterrent formulations |
12:00 PM | Lunch |
Afternoon Session Moderator: Jeff Hemenway | |
1:00 PM | Keynote: Associate Prof. Vincent Mazel, Ph.D., University of Bordeaux, Institute of Mechanics and Engineering: Strategy for the study of the viscoelastic properties of pharmaceutical tablets using a compaction simulator |
2:00 PM | Johny Bertels, Janssen, Johnson & Johnson Compaction simulation: one piece of the tablet development puzzle |
2:30 PM | Break |
3:00 PM | Jasmine Rowe, Bristol-Myers Squibb Bridging the gap: using compaction simulation to correlate drug substance properties to drug product decisions |
3:30 PM | Michael Keeney et al., Gilead Sciences The Use of Compaction Simulation to Maximize Interfacial Strength of Bilayer Tablets |
4:00 PM | Flash Presentations Moderated by: Edward Yost, Genentech Helen Hou, Genentech Impact of method of preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of co-precipitation and spray drying Jovana Radojevic, Drexel University Effect of External Load on the Evolution of Post-Compaction Properties of Sodium Chloride Compacts and its Mixtures Edward Yost, Genentech Quantitative X-ray Micro-Computed Tomography Assessment of Internal Tablet Defects Martin Bennett, Huxley Bertram The effect of production press stiffness on tablet strain rate Yoshihiro Hayashi, University of Toyama Modeling of quantitative relationships between physicochemical properties of APIs and tablet properties using a random forest Cosima Hirschberg, University of Copenhagen The effect of atomic layer deposition (ALD) on critical powder characteristics Anne Skelbaek, University of Copenhagen Quantification of fragmentation of pharmaceutical materials during tableting |
5:00 PM | Posters & Networking Reception |
7:00 PM – 10:00 PM | CSF Dinner Steelhead Brewery |
Wednesday, June 13th 2018
CSF Day 28:00 AM | Breakfast |
8:30 AM | Introduction |
Morning Session Moderator: Bhavi Mittal | |
9:00 AM | Keynote: Prof. Chuan-Yu (Charley) Wu, Ph.D., University of Surrey – Guildford, College of Engineering The development of in silico process models for roll compaction |
9:45 AM | Jie Ren, A.Tantuccio, W. Blincoe, J.Mandur, B.Smith-Goettler, J.DiNunzio, Merck & Co. Development of a continuous blending-compression process using compaction simulation |
10:15 AM | Break |
10:30 AM | Jennifer Sinclair Curtis, University of California, Davis Using DEM simulation to aid in the design of pharmaceutical processes |
11:00 AM | Jens Dhondt, et al., Ghent University, J&J Janssen The development of a predictive tableting platform for lab scale direct compression |
11:30 AM | Gulsad Kucuk, Yin-Chao Tseng, Xiaorong He, Boehringer-Ingelheim Application of mechanistic modelling to improve the tablet compaction process |
12:00 PM | Lunch |
Afternoon Session Moderator: Jeff Katz | |
1:00 PM | Keynote: Prof. Dale Eric Wurster, Ph.D., University of Iowa, College of Pharmacy Compression Calorimetry |
2:00 PM | Chen Mao, Genentech Tablet ejection force and its sensitivity to lubrication a compaction simulation study |
2:30 PM | Break |
3:00 PM | João Henriques, S. Doktorovova, P. Lino, M. Paiva, J. Vicente, Hovione How to develop an amorphous solid dispersion in tablets with less than 30g of API |
3:30 PM | Ira S. Buckner & Pradeep Valekar, Duquesne University Rational formulation design using individual component property based predictions |
4:00 PM | Bhavi Mittal & Vrushali Waknis, Allergan Making a business case for a compaction simulator in the age of pharmaceutical outsourcing |
4:30 PM | Concluding Remarks |
5:00 PM | Networking Cocktail Event |
The Scientific Committee is chaired by Charles Yang, Principal Scientific Manager, Formulation
Development & GMP Manufacturing Operations, Genentech.
The committee also includes:
- Jeff Hemenway, Gilead
- Jeff Katz, Amgen
- Tracey Mascaro, Merck
- Bhavi Mittal, Allergan