About Us
The Compaction Simulation Forum
The Compaction Simulation website is a resource for scientists, engineers, academics and equipment manufacturers. The intent is for CompactionSimuation.com to be a one stop resource where you can find the latest research, equipment, technology and conferences.
As high-speed hydraulic simulators and mechanical replicators are now widely used in the Pharmaceutical Industry and in Academia, the number of publications on this topic continues to rise. Many new techniques are arising, like computational methods which can predict what occurs during the compaction process. What the Compaction Simulation website aims to provide is a location for scientists to find the latest advancements.
The importance of compaction simulation
Simulation of pharmaceutical powder compaction processes (die compaction, roll compaction, capsule compaction) is becoming increasingly important for drug product development. By investigating properties early in development, a better understanding is obtained and early characterisation, provides the ability to reduce development timelines.
As Pharmaceutical APIs are becoming increasingly expensive, compaction simulation enables scientists to reduce the amount of ingredients required to support characterisation, preformulation/formulation studies and scaling exercises, thus delivering an effective rational design process in a materials-sparing environment.
As a support to crystal engineering and particles design, compaction simulation provides early characterisation and tabletability assessment of new compounds.
Compaction Simulation’s role in Quality by Design (QbD): Powder compaction simulation involves advanced technology and inter-disciplinary knowledge. There are many unknowns about the technology, which has gained attention from industry and academia; QbD concepts are now being widely advocated by FDA regulators. Simulating what occurs during a compaction process with minimal amount of material has a central role in pursuing QbD as a time- and cost-efficient complement to on-press experimentation.
The Compaction Simulation Forums, 2012-2022:
The first eight Forums have generated a lot of interest and showcased many cutting-edge presentations which are listed on this website. Key metrics of the Forums are summarized as follows: