[learn_more caption=”Changquan Calvin Sun”] Biography: Dr. Sun is currently Associate Professor of Pharmaceutics at University of Minnesota, USA and Visiting Professor at University of Copenhagen, Denmark. He worked in the pharmaceutical industry (Amgen and Pfizer) during 2000 – 2008. He joined the University of Minnesota as an Assistant Professor in 2008 and was promoted to the current position in 2013. Dr. Sun received his Ph.D. in Pharmaceutics from the University of Minnesota in 2000. His research focuses on 1) crystal and particle engineering for superior powder flow and compaction properties; 2) understanding and control of common pharmaceutical unit operations, e.g., blending, granulation, and tableting. Dr. Sun is an expert in the areas of solid-state chemistry, tablet formulation design, and powder technology. He has published more than 70 peer-reviewed papers in these areas. Sun Research: http://www.pharmacy.umn.edu/faculty/sun_changquancalvin/index.htm Sun Publications: http://scholar.google.com/citations?user=RCkrEp8AAAAJ&hl=en [/learn_more]

Abstract: Poor tabletability of drugs is a well-recognized problem in pharmaceutical tablet manufacturing. When drug loading is high, formulation approach is often inadequate or ineffective to address this problem. An effective approach is to fundamentally modify mechanical properties of drug crystals to enable successful tableting even at a very high loading. In this talk, the linkage between crystal mechanical properties and tabletability and that between crystal structure and mechanical properties will be presented. On this basis, crystal engineering promises to be an extremely useful tool to enable tablet development, especially if it is carried out early in the development of a drug.   Recent examples will be given to illustrate the principles.