Leonie Wagner-Hattler, Adrian Baumgartner
F-Hoffmann – La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland

Developing minitablets poses some unique challenges and considerations in terms of granule/powder properties as well as intrinsic mechanical characteristics of the formulations. Aspects such as bulk density of granules, flowability and particle size distribution of granules play an important role for successful manufacturing of minitablets. But also other contributors like e.g. punch design play an important role for successful production. In this talk a proposal on how to develop minitablets on a Styl’One evolution is presented and discussed. Key aspects such as roller compaction simulations and compression profile simulation are highlighted and limitations such as segregation propensity and flow properties are critically considered.
To conclude, additional thoughts on complementing work on the compaction simulator are proposed as an outlook of the work.