Malla Reddy
Department of Chemical Sciences
Indian Institute of Science Education and Research (IISER)
Kolkata, Mohanpur-741252
West Bengal, India
e-mail id: cmreddy@iiserkol.ac.in; cmallareddy@gmail.com
Understanding structure-mechanical property correlation is a key element in materials science, engineering and pharmaceutical formulations that underlies the successful design of materials.1-6 A considerable amount of time and resources are spent on formulation design and manufacturing process development in pharmaceutical industries. The extent of spending in this context could be directly linked to the solid forms’ mechanical properties and the underlying crystal structure. Although a wide range of formulation techniques are available to deal with poor mechanical properties of active pharmaceutical ingredients (APIs), they are mostly developed and applied by empiricism which however usually comes without the much desired robust qualities. In our ongoing study, the knowledge gained from structure-mechanical property correlation in co-crystals and polymorphic molecular solids is shown to be useful to understand and engineer tabletability properties of APIs. The results on plastic7 and elastic bending, shearing and brittle type crystals support the effectiveness of crystal structure based approach for API processing and formulation for pharmaceutical and fine chemical industry.
[1] P. P. Bag, M. Chen, C. C. Sun and C. M. Reddy, CrystEngComm, 2012, 14, 3865
[1] C. M. Reddy; G. R. Krishna; S. Ghosh, CrystEngComm 2010, 12, 2296.
[2] S. Karki; T. Friščić; L. Fábián; P. R. Laity; G. M. Day; W. Jones Adv. Mater. 2009, 21, 3905
[3] J. C. Burley; M. J. Duer; R. S. Stein; R. Vrcelj Eur. J. Pharm. Sci. 2007, 31, 271.
[4] S. Chattoraj; L. Shi; C.C. Sun CrystEngComm 2010, 12, 2466.
[5] C. C. Sun; H. Hou Cryst. Growth Des. 2008, 8, 1575.
[6] C. C. Sun Int. J. Pharm. 2006, 326, 94.
[7] M. K. Panda, S. Ghosh, N. Yasuda, T. Moriwaki, G. D. Mukherjee, C. M. Reddy and P. Naumov, Nature Chem. 2015, 7, 65-72.