Monday, June 5th 2023

5:00 PM – 7:00 PM

Opening Reception

Tuesday, June 6th 2023

Tuesday AM: Continuous Improvement
8:30 AM	Introduction & Program Preview
	Morning Session Chair: Edward Yost, Sr. Principal Scientific Researcher at Genentech
8:35 AM	Keynote: Ajaz S. Hussain, Ph.D. Continual Improvement and Continuous Development
9:30 AM	Vincent Mazel, Professor at University of Bordeaux Capping of biconvex tablets: towards a better understanding and prediction
10:00 AM	Break
10:20 AM	Ariel Muiliadi, Senior Principal Scientist at Genentech Compaction simulator use at Genentech – 5 Years Later
10:50 AM	Pingjun Tang, Vertex Understanding air-entrapment induced fissures during tablet compression through tooling design
11:30 AM	Elcin Gencer, Senior Manager, Data Sciences at Amgen In Silico Modeling of Roller Compaction Processes for Scale-Up and Tech Transfer: One Step Closer to Digital Twins
12:00 PM	Lunch
Tuesday PM: Particle-Scale Modeling
1:00 PM	Afternoon Session Chair: Sean Garner
1:05 PM	Keynote: Jeremy Lechman, Sandia National Laboratories Particle-scale modeling of powder compaction
2:00 PM	Shawn Zhang, DigiM Solution 3D Micro-imaging in the Quantitative Characterization, Mechanistic Understanding, and Continuous Manufacturing of Drug Products
2:30 PM	Peyman Aminpour, Ph.D., Material Scientist III, Thermo Fisher Scientific Process Understanding and Scale-up of Pharmaceutical Blending Using Discrete Element Methods (DEM)
3:00 PM	Break
3:20 PM	Dan Skomski, Principal Scientist at Merck Computer Vision for Defect Detection in Drug Products
3:50 PM	Flash Poster Presentations Delphine Ach-Hubert, MEDELPHARM Johnathan Cummings, Alkermese
4:30 PM	Posters & Networking Reception
6:00 PM – 9:00 PM	CSF Dinner

Wednesday, June 7th 2023

Wednesday AM: Segregation During Die Filling
8:30 AM	Introduction
8:35 AM	Morning Session Chair: Jasmine Rowe
8:45 AM	Keynote: Antonios Zavaliangos, Ph.D. Old and New ideas on the fracture of pharmaceutical tablets and some practical directions forward
9:30 AM	Rahul Haware, Ph.D., Director of Scientific Support and New Business Development at Natoli Scientific Alternative Approaches for Traditional Heckel Analysis
10:00 AM	Break
10:20 AM	Steven Dale, Senior Principal Scientist, Continuous Manufacturing at Vertex Pharmaceuticals Assessment of compression models for use in a dry granulation line digital twin
10:50 AM	Helen Hou, Senior Principal Scientist at Genentech Assessment of Physical-mechanical Properties of Amorphous Solid Dispersions
11:20 AM	Danny van der Haven, Ph.D. student simulating powder compaction Tablet ejection: a systematic comparison between force, static friction, and kinetic friction
11:50 AM	Jerry Klinzing, Principal Scientist at Merck A 3D finite element modeling study of debossing design, position, and cup depth on tablet density
12:20 PM	Lunch
Wednesday PM: Solid Form Importance
1:10 PM	Afternoon Session Chair: Pingjun Tang
1:15 PM	Keynote: Eric J. Munson Impact of Variability in Magnesium Stearate on Lubrication Properties and Dissolution Rates of Tablet Formulation
2:00 PM	Sean Garner, AbbVie R&D Application of Peridynamics to Predict Pharmaceutical Tablet Robustness
2:30 PM	Cetin Cetinkayaa, Jesanis Endowed Chair Professor and CTO at Pharmacoustics Technologies Ultrasonic Methods for Real-Time Release Testing of Compressed Orals Solid Dosage Forms
3:00 PM	Break
3:20 PM	Chen Mao, Distinguished Scientist at Genentech The classic Johanson model for roller compaction can be substantially simplified using rolls with non-smooth surface
3:50 PM	Ending Keynote: Prof Csaba Sinka Modeling Of Tablet Capping
4:30 PM	Kevin Bittorf – Concluding Remarks
5:00 PM	Networking Cocktail Event