Cetin Cetinkayaa, Xiaochi Xub, Vivek S. Davec, Justin Kuriyileld, Stephen W. Hoage
a,b Clarkson University, 8 Clarkson Ave. Potsdam, NY13699-5725, USA
c,d St. John Fisher College, Wegmans School of Pharmacy, Rochester, NY 14618, USA
e School of Pharmacy, University of Maryland, Baltimore, MD, 21201, USA
Purpose. Predicting tablet capping in terms of process parameters (e.g. compaction pressure and speed) and formulation properties is essential in tablet production. In current work, our objective is to demonstrate that a non-destructive contact ultrasonic approach can be used for detecting capping risk in the pharmaceutical compacts prepared under various compression forces and speeds.
Methods. Non-destructive contact ultrasonic approach
Results. The effect of compaction speed and pressure on the porosity and tensile strength of the resulting compacts is quantified, and related to the compact acoustic characteristics and mechanical properties.
Conclusions. The detailed experimental approach and reported wave propagation data could find key applications in determining the bounds of manufacturing design spaces in the development phase, predicting capping during (continuous) tablet manufacturing, as well as online monitoring of tablet mechanical integrity and reducing batch-to-batch end-product quality variations.
Cetin Çetinkaya
Prof. Çetinkaya’s background is in acoustic/thermoelastic wave propagation, dynamics, vibration, computer algebra, and computational/analytical mechanics. His applications/interest areas include nano/micro-particle and biological cell adhesion, acoustic micro-devices, drug delivery modalities, laser-based nondestructive testing/evaluation, and non-invasive real-time monitoring of manufacturing processes. He received his B.S. in Aeronautical Engineering from Istanbul Technical University, and M.S. and Ph.D. in Aerospace Engineering from the University of Illinois at Urbana-Champaign, respectively. Currently, he is a professor of mechanical engineering at Clarkson University, and is serving as the director of the Photo-Acoustics Research (PAR) Laboratory. Prof. Çetinkaya is an ASME Fellow.