[learn_more caption=”Peter Kleinebudde”] Biography: Prof. Peter Kleinebudde is pharmacist and finished his dissertation at the University Kiel in 1987. He then spent some years at Glaxo GmbH, Germany, in Pharmaceutical Development and Bulk Production. 1997 received the German ‘Habilitation’ about work on pellets. During a stay at the Royal Danish School of Pharmacy in Copenhagen he was appointed as associate professor at the University Halle-Wittenberg in 1998. From 2002 to 2003 he was dean of the School of Pharmacy. In 2003 Peter was nominated as full professor at the Heinrich-Heine-University Duesseldorf. Since 2011 he is chair of the Department of Pharmacy and member of the academic senate of the University.  Peter was president of the International Association for Pharmaceutical Technology (APV) from 2002 to 2010 and since then he is head of the APV focus group Solid Dosage Forms. He is a member of the editorial boards of Eur J Pharm Biopharm, AAPS PharmSciTech, J Pharm Sci and Pharm Dev Tech. He is chair of the Powder Working Party and member of Group 12 of the European Pharmacopoeia. In 2004 he was appointed as AAPS Fellow. In 2013 he received the Dr. honoris causa degree from the University of Szeged (Hungary).  His main research interests are solid dosage forms and pharmaceutical processes like roll compaction/ dry granulation, extrusion and coating.[/learn_more]

Compactability and tabletability of different organic and anorganic materials are suffering from roll compaction. Different mechanisms have been postulated for this phenomenon. Depending on the way of tableting and lubrication effects of lubrication, granule size and granule hardening can be differentiated. On approach to take the granule hardening into consideration is the Unified Compaction Curve Model. Based on own and published data the different mechanisms are discussed.