[learn_more caption=”Sayantan Chattoraj, Ph.D”] Dr. Sayantan Chattoraj received his Ph.D. in Pharmaceutical Materials Science from University of Minnesota. His advisor was Prof. Changquan Calvin Sun. Currently, Dr. Chattoraj is working in Global Formulation Development at GlaxoSmithKline, Upper Providence, and acts as the drug product lead in CMC for late phase molecules from Ph 1 to commercial launch. His current focus is on the manufacturability of oral solids, including material sparing prediction of compaction & flow, product & process robustness, design space & scale up. [/learn_more]  

The purpose of this work is to assess the manufacturability of placebo granules prepared by continuous twin screw wet granulation, as function of water loading and number of kneaders.  A comparison of the granule manufacturability metrics is made with those produced by batch wet granulation, using   compaction simulation.  The processability of the granules is partly explained by comparing the granule morphology and size.