Performance of formulated APIs into RC tablet: From the Compaction Simulator to a Production Scale Roller Compactor

Claire Tridon
GlaxoSmithKline

This presentation will detail how the characterisation of the mechanical deformation properties of the active pharmaceutical ingredient (API) can be used in combination with excipients to identify a robust product for commercialisation.  This case study in particular describes how the simulator can successfully predict the performance of a roller compacted product at commercial scale.