The development of compressible beads for manufacturing controlled release tablet

[learn_more caption=”Frederick Osei-Yeboah”] Mr. Osei-Yeboah is currently a Ph.D. student at the Department of Pharmaceutics, University of Minnesota. His research interest is on materials engineering for superior compaction performance of pharmaceutical powders. Frederick’s expertise ranges from solid-state characterization, to formulation development, and to process optimization. He has two published papers and holds the David and Marilyn Grant Fellowship in Pharmaceutics.[/learn_more]

The preparation of tablet using drug layered controlled release beads is an important goal to the pharmaceutical industry.   However, this effort is challenged by poor compressibility of functionally coated beads.  It is usually difficult to make sufficient strong tablets from such beads without compromising the integrity of the functional coating layer.  In this talk, we will discuss how a top coating strategy (using highly bonding polymers) can be used to overcome this problem.